I think that could run safely. Now my question. Could 1 wire it up with an cat7 cable from the Multiplexer to each single SHT31... with 5-8m cablelength.
So it could be possible to attach up to 8 rooms to one ESP8266.
What do you think... could it run or is the cable TO LONG from the ESP/MULTIPLEXER to each SHT31?
Would it be better using an ESP32 instead of the ESP8266?
If someone has already tried such an scenario... let us know

Wiring it up as described I don't need an ESP in each room, but only one each 1-8 rooms.
Then I would also attach 10-15 DS18b20 sensors on the heating return lines.
All that stuff on an ESP8266? we will see if it will be possible. The limitation to 12 devices in ESPeasy will be a "problem" to be solved. eventually in a custom compiled version...